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OncoNov delivers daily updates on the latest breakthroughs in cancer research, diagnostics, clinical trials, and treatment innovations. Our mission is to keep clinicians, researchers, and patients informed with concise, reliable, and actionable insights, helping the oncology community stay ahead in the rapidly evolving landscape of cancer care.

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Zanidatamab Combinations Outperform Trastuzumab in Landmark Trial for HER2-Positive Gastroesophageal Cancer

Top-line results from the Phase 3 HERIZON-GEA-01 trial show that zanidatamab-based treatment combinations significantly improve outcomes for people with previously untreated HER2-positive locally...

Tafasitamab Triplet Shows Strong Benefits for Relapsed Follicular Lymphoma in Phase 3 Trial

A new recommendation supports approving the combination of tafasitamab, lenalidomide, and rituximab for adults with relapsed or refractory follicular lymphoma who have already received at least one...

Immunotherapy Combo Shows Strong Survival Gains in Aggressive Chondrosarcoma, FLAIL-C Trial Finds

The FLAIL-C Phase 2 trial evaluated whether adding anti-PD-1 immunotherapy to the tyrosine kinase inhibitor anlotinib could improve outcomes for patients with advanced, unresectable chondrosarcoma...

New Imaging Breakthrough Quickly Predicts Cancer Drug Response in Patient Tumor Models

A new imaging method is helping researchers predict how cancer drugs will work in patient-derived tumor models more quickly and accurately. Precision medicine aims to match the right treatment to each...

New MST-AI Method Boosts Skin Cancer Detection Accuracy for Darker Skin Tones

Researchers have introduced a new AI method called MST-AI that aims to make skin cancer detection more accurate and fair for people with darker skin tones. Many current AI tools used to detect...

MUC18-Targeted ADC AMT-253 Shows Strong Early Efficacy in Melanoma and Gynecologic Cancers

AMT-253, a MUC18-targeted antibody-drug conjugate, has shown encouraging results in two phase 1 melanoma studies. Among 56 evaluable melanoma patients, the overall response rate was 28.6%, with 15...

New Metal-Based Complexes Poised to Replace Cisplatin in Next-Generation Cancer Therapy

Organometallic complexes—cancer-fighting compounds built around metal-carbon bonds—are emerging as a more selective alternative to traditional platinum drugs like cisplatin. While platinum...

New Insights Into ROS and Autophagy Reveal Why Thyroid Cancer Resistance Is Rising

Thyroid cancer is rising quickly worldwide and is expected to become the fourth most common cancer by 2030. Although survival rates are high, drug resistance and reduced sensitivity to radioactive...

NaPi2b-Targeted ADC TUB-040 Shows Promising Results in Platinum-Resistant Ovarian Cancer

NaPi2b, a sodium-dependent phosphate transporter protein, is once again gaining attention as a therapeutic target for platinum-resistant ovarian cancer, where treatment options remain limited. NaPi2b...